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To understand the differential gene expression of M.leprae using
genomic approaches
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Ultrastructural study of
leprosy granuloma and blood vessels using immunoelectron-microscopy
and molecular methods
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Investigations on the
relationship between hormone levels and progression of disease in women
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Structural studies of cell transition in pathogenesis
of mycobacterial
diseases
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Three dimensional study of mycobacterial granuloma to understand disease process:
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Auto-antibodies in children leprosy cases
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Nitric oxide metabolites in leprosy patients with
type 2 reactions
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Study of anti-cytokine antibodies in leprosy
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Molecular epidemiological studies using RAPD, IS
6110, AFLP and other methods
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Quantitative assessment of mutations by real time PCR
of genes encoding for resistance
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Molecular methods for drug resistance in leprosy and
Study drug resistance in animal model
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Drug permeability and pharmacokinetics
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Proteomic approaches to understand mechanisms of
intracellular parasitization and drug resistance etc.
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Immunotherapy in borderline leprosy
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Electrophysiological study of peripheral nerves in
leprosy and diabetes mellitus to understand prognostic markers
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Early prevention of deformities and different
surgical intervention studies
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Study on social aspects
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Develop serological techniques and DNA probes for
diagnosis of leprosy at a very early stage
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Design new drug regimen to shorten treatment and for
preventing relapse
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Follow up patients released from treatment to assess
relapse rate
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Molecular biology and genomics of
mycobacteria
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Development of early warning system for JE and dengue
Molecular based tools
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Host parasite interaction in dengue
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Role of non-structural proteins in development of
vaccines
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Immunoprotective and immunopathogenic mechanism in JE, and dengue virus infection
in mice.
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Immunopathogenic
mechanisms and pathophysilogy of dengue hemorrhagic
fever in humans
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Role of rats in the transmission of HEV
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Study of
immune response and cytokine patterns in patients with HCV
infection
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Study on the efficacy and safety of available
antiviral drugs against influenza
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Evaluation of Membrane Filters for sewage treatment
and water purification plants
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Effect of ecological changes on Aedes
aegypti in urban and semiurban
eradication program
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Assessment of role of HCV HVR1 and host HLA status in
progression
of hepatitis
C
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Assessment of host/virus factors leading to fulminant hepatitis E & A
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Genomic characterization of hepatitis E and A viruses
circulating in India.
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Monitoring of sewage and Water treatment plan for the
presence of HAV and HEV
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Development of
ELISA for the diagnosis of Adeno virus
infection
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Generation of
HIV-1 subtype C based DNA vaccine candidates and
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assessment of
prime-boost immunization strategy in mouse model
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Development of vaccine for hepatitis E + A Virus
Infection
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Development of a combined ELISA for the detection of
anti HCV, anti-HIV antibodies and HbsAg
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Preparation of egg yolk antibodies against
rotavirus
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To detect transmission of OPV strains
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Full genome sequence analysis of vaccine virus
isolated from AFP cases and environment
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Role of enteroviruses in
CNS diseases
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Development of new rapid diagnosis and strain
characterization tools
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New Enterovirus types
(detection and characterization)
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Isolation and genotype characterization of measles
virus
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Epidemiology of measles
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Developing PCR for measles virus detection
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Genotyping of HBV infection in different parts
of India to
point out the genomic diversity in HBV infection and prediction of disease
transmission to the genotype of the individual.
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Natural history studies in HIV infected individuals
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Identify immunological parameters for pathogenesis,
progress and therapy in infection
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Assessment of impact of intervention in mother to
child transmission
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Development of new products (vaginal microbicides) and evaluation of efficacy of new as well as
old products.
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Drug resistance pattern of the virus in different
parts of the country.
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Initiate basic, operational and preventive studies on
HIV-TB
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Initiate studies on chemoprophylaxis of TB in HIV-TB
patients.
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Development of HIV-AIDS vaccine and clinical trials
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Development of combined HIV-TB vaccine
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HIV/AIDS Disease Burden and Socioeconomic impact.
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Antiretroviral therapy and various aspects related to
the ART.
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Social behavioural studies.
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Hospital field based surveillance system for Diarrhoeal
Diseases to monitor changing spectrum of enteric pathogens and to identify
newer pathogens.
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Development of tools for disease surveillance
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Development of DNA probe or PCR based diagnostic
system for diagnosis of E. histolytica and cryptosporodium parvum by molecular biological tools.
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Studies on Molecular Epidemiology of Enteric
Pathogens - Genetic characterization of V. cholerae
strains.
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Molecular characterization of multi-drug resistant shigella flexneri.
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Studies on rotavirus surveillance on disease burden.
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Studies on Rotavirus strain diversity.
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Molecular characterization of viruses
viz. rotaviruses, human calcivirus, arbovirus, hepatitis virus.
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Development of effective superior oral rehydration solution.
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Impact of micronutrients in management of diarrhoea.
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Vaccine trial studies - typhoid, cholera
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Estimation of malaria disease burden.
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Development of sustainable vector control strategies.
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Cost effectiveness studies on various intervention
measures.
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Bionomics of malaria vectors.
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Molecular characterisation and parasite biology
by development of molecular markers to characterize P. vivax
and P. falciparum isolates.
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Development of molecular and immunodiagnostic
methods.
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Identification of members of An. dirus
and an. minimus complexes using molecular diagnostic
techniques.
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Studies on identification of sibling species.
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Genetic structure studies of An. culicifacies
and fluviatilis using molecular markers.
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Monitoring of therapeutic efficacy of commonly used antimalarials and alternative treatment regimens for
resistant parasite.
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Evaluation of rapid diagnostic kits for malaria
diagnostics.
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Management of insecticide resistance.
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Application of Remote Sensing and GIS in Epidemiology
of malaria.
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Development of epidemic forecasting tools for malaria
using environmental parameters.
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Social marketing, distribution, community acceptance
and evaluation of insecticides impregnated bednets /
curtains etc. for personal protection.
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Health Impact Assessment and Management Information
Systems (MIS) and its efficiency.
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Development of field site for vaccine trial.
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Estimation of burden of disease due to lymphatic
filariasis.
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Development of diagnostic/monitoring tools for filaria vectors.
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Development of intervention strategy for filariasis
with emphasis on drug delivery mechanism, advocacy, monitoring and evaluation, cost
effectiveness.
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Genome mapping of filaria
vector species and benefit.
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Development of newer tools for diagnosis and control
of filaria
vectors (tools for vector control, parasite control, surveillance and morbidity
management, molecular/ immunological/ genetic markers and diagnostics)
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Epidemiological studies including mapping,
stratification and establishing cause and effect relationship using Geographic
Information System (GIS) site specific dynamics of infection, transmission and
disease and estimation of disease and economic burden.
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Studies to understand the immunological and molecular
basis of host parasite interaction.
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Studies on drug susceptibility/develop appropriate
drug regimen.
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Studies on dynamics of disease progression for
disease management.
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Effectiveness of immuno-prophylactic
at individual and community level.
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Studies on development of macrofilaricidal
drugs.
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Application of decision making tools, particularly
mathematical models for forecasting the trend of infection/disease and
predicting the long term impact of intervention and selection of appropriate
site specific strategy and duration of intervention(s) (Statistical
/Mathematical models, economic evaluations, rapid assessment procedures and
mapping, sampling protocols, algorithms for morbidity management, molecular
epidemiology, DNA fingerprinting for exposure studies)
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Initiate molecular epidemiology studies to understand
transmission dynamics.
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Use GIS and satellite images to develop an epidemic
prediction tool.
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Diagnostic tools for early detection of visceral leishmaniasis and post kala-azar
dermal leishmaniasis (PKDL).
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Evaluation of various diagnostic tools.
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Cloning and characterisation
of stage specific genes from clinical isolates of Leishmania
donovani.
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Identification of specific genes of L. donovani using genomic micro-assays.
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Study the biochemical and molecular characteristics
of SAG responsive and unresponsive isolates.
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Research and development of leishmania
vaccine
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Behavioural surveillance
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Estimation of disease burden in tribals.
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Study of risk factors for life style disease among
tribals.
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Studies on Haemoglobinopathies in the Tribal
population.
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Impact of health education and counselling
on knowledge, attitude and practices of sickle cell.
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Health and morbidity profile studies in primitive
tribes.
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Study on the causes of childhood mortality and
morbidity and prevalence of anaemia and iodine
deficiency disorders among the primitive tribes.
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Health and nutritional status of tribes with special
focus on micronutrients.
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Studies on utilization of traditional system of
malaria in dwindling tribes
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Studies on transmission dynamics of malaria.
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Epidemiology and etiology study of acute diarrhoea
disease.
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Stratification of high malarious
areas based on vector species prevalence in different eco-epidemiological
systems for planning effective situation specific malaria control strategy - a
multi centric study
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Studies on Characterization of P. falciparum
prevalent in tribal areas
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