REGIONAL MEDICAL RESEARCH CENTRE

BHUBANESWAR - 751023


(Established in 1981)

  REGIONAL MEDICAL RESEARCH      CENTRE

Publications

Phone: 0674 -2301332
Fax: 0674 -2301351
Email : skk@icmr.org.in
Website :  http://www.rmrcbbsr.gov.in/
Scope of Activities:

  • Situated at Bhubaneswar, Orissa, Regional Medical Research Centre (RMRC, Bhubaneswar)
    conducts interdisciplinary research on locally prevailing communicable and non-communicable
    diseases such as filariasis, malaria, viral hepatitis and other viral diseases, tuberculosis, diarrhoeal
    disorders, haemoglobinopathies and allied disorders, tribal health and malnutrition in the state
    and neighboring areas.
  • The Centre while maintaining focus on operational and applied aspects of the diseases of
    regional importance and related research as required, is placing greater emphasis on translational
    research.
  • The Centre also provides support to the state health departments and national programmes in
    disease surveillance activities in form of epidemic investigation and diagnosis, evaluation and
    training;
  • Provides HRD activities in the form of training and research to post graduate students for Ph.D/
    MD degree, M.Sc /M.Phil. dissertation and short term training is also provided to the doctors
    and technicians, from state health departments and NVBDCP, Delhi. In particular, the centre has
    been regularly imparting training to malaria technical supervisors (MTS) of different states of
    the eastern region of the country on different aspects of malaria including Lot quality assurance
    sampling (LQAS).

Thrust Areas:

The following are the thrust areas of RMRC, Bhubaneswar

Filariasis

  • Undertakes studies to find out the dynamics of disease progression for disease management;
    to develop an intervention strategy through clinical trials with emphasis on drug delivery
    mechanism, advocacy, monitoring and evaluation; to understand the immunological
    and molecular basis of host parasite interaction to develop immunodiagnostic/ immunoprophylactic
    tools as R & D activity. Early lymphatic pathological changes in infected children
    in sub clinical and early clinical phase are studied to see whether DEC and albendazole can
    reverse lymphatic abnormality in uninfected children. Molecular Xeno-monitoring of vector
    is being used as a useful tool for evaluating the success and progress of filariasis control
    programs by MDA.

Malaria

  • Carries out molecular characterization of incriminating parasites; therapeutic efficacy of
    commonly used anti-malarials and alternative treatment regimens for resistant parasite;
    studies on identification of genetic factors in human involved in natural resistance to malaria
    infection; studies on identification of sibling species and genetic structure of malaria vectors
    using molecular markers; studies on application of remote sensing and GIS in epidemiology
    of malaria to develop strategy for vector control .Development and optimization of new
    diagnostic tools for malaria like LAMP assay.

Viral hepatitis

  • Undertakes research works on genomic characterization of hepatitis E and A viruses and
    genotyping of HBV infection circulating in different parts of Orissa.

Diarrhoeal disorders

  • Undertakes studies on hospital and field based surveillance system for diarrhoeal
    diseases to monitor spectrum of enteric pathogens; molecular epidemiology and genetic
    characterization of V. cholerae strains and other diarrhoeal pathogens.

Haemoglobinopathies and allied disorders

  • Study the distribution pattern of genetic abnormalities, clinical spectrum and molecular
    characterization of abnormal haemoglobin molecules; G6PD deficiency prevalent in Orissa
    and their clinical significance.

Nutrition and tribal health

  • Studies on the prevalence of anaemia, vitamin A and iodine deficiency disorders among
    the primitive tribes; health and nutritional status of different tribes with special focus on
    micronutrients to develop suitable intervention strategy; prevalence of haemoglobinopathies
    in the tribal population.

Tuberculosis

  • Culture facility has been established at the Centre to identify multi drug resistance (MDR)
    and related research issues in this region.

Virology

  • Laboratory is being established with facilities for viral isolation, viral antigen detection, viral
    serology and molecular diagnostic virology including sequencing and to conduct outbreak
    investigation of viral diseases of the region.

Translational research

  • The centre has undertaken translational research on identification of malaria vectors by
    molecular method, diagnostic tool for V. cholerae, development of candidate vaccine for
    filariasis, diagnostic tool for identification of malaria parasite by loop mediated isothermal
    amplification (LAMP) assay.
Human Resource Development :

  • M.Sc Dissertations: Sponsored from different universities of Orissa and other parts of the country including students of ICMR short term fellowship programme.
  • Other training programmes: Short term training to the doctors and technicians/paramedics from state health departments and NVBDCP, Delhi. The Centre also provides training on mosquito control to staff of different municipal corporations of the state.
Recognition for Doctorate/Masters by a University:

Ph.D. Programme: Recognized by Utkal University, Bhubaneswar (Orissa) and Kalyani University, Kalyani (West Bengal).

Major Achievements:

Significant achievement of RMRC, Bhubaneswar are the following

  • First to standardize tissue tonometry for assessing progression of lymphoedema.
  • First to describe the lymphatic nodules as clinical manifestation of bancroftian filariasis.
  • First to report the use of ivermectin for treatment of scabies.
  • Developed the urban strategy of mass drug distribution (MDA) for improvement of
    compliance of single dose DEC for elimination of LF.
  • Described the potential anti-microfilarial role of ALT2 and CPI2 recombinant antigens.
  • Identified a candidate antigen (DssdI) for development of vaccine against bancroftian
    filariasis
  • Described a new variant of G6PD enzyme called “G6PD Orissa” among tribal and non-tribal
    populations of India.
  • Identified a novel allele in the intron 4(VNTR) of endothelial nitric oxide synthase (eNOS) in
    our population and association of eNOS polymorphism against cerebral malaria.
  • Developed a single tube PCR method to identify mosquito species, presence of sporozoite
    and kind of blood meal taken by the vector mosquito.
  • Identified pentoxyfiline as an adjunct drug for treatment of cerebral malaria.
  • Established a close link with state health system of Orissa to transfer knowledge regarding
    vector borne and diarrhoeal diseases.
  • Signing of a memorandum of understanding (MoU) between the state health department
    Orissa and ICMR to facilitate operational research on cholera control strategy by the Centre
    at Rayagada.

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