REGIONAL MEDICAL RESEARCH CENTRE
BHUBANESWAR - 751023
- Situated at Bhubaneswar, Orissa, Regional Medical Research Centre (RMRC, Bhubaneswar)
conducts interdisciplinary research on locally prevailing communicable and non-communicable
diseases such as filariasis, malaria, viral hepatitis and other viral diseases, tuberculosis, diarrhoeal
disorders, haemoglobinopathies and allied disorders, tribal health and malnutrition in the state
and neighboring areas.
- The Centre while maintaining focus on operational and applied aspects of the diseases of
regional importance and related research as required, is placing greater emphasis on translational
- The Centre also provides support to the state health departments and national programmes in
disease surveillance activities in form of epidemic investigation and diagnosis, evaluation and
- Provides HRD activities in the form of training and research to post graduate students for Ph.D/
MD degree, M.Sc /M.Phil. dissertation and short term training is also provided to the doctors
and technicians, from state health departments and NVBDCP, Delhi. In particular, the centre has
been regularly imparting training to malaria technical supervisors (MTS) of different states of
the eastern region of the country on different aspects of malaria including Lot quality assurance
The following are the thrust areas of RMRC, Bhubaneswar
- Undertakes studies to find out the dynamics of disease progression for disease management;
to develop an intervention strategy through clinical trials with emphasis on drug delivery
mechanism, advocacy, monitoring and evaluation; to understand the immunological
and molecular basis of host parasite interaction to develop immunodiagnostic/ immunoprophylactic
tools as R & D activity. Early lymphatic pathological changes in infected children
in sub clinical and early clinical phase are studied to see whether DEC and albendazole can
reverse lymphatic abnormality in uninfected children. Molecular Xeno-monitoring of vector
is being used as a useful tool for evaluating the success and progress of filariasis control
programs by MDA.
- Carries out molecular characterization of incriminating parasites; therapeutic efficacy of
commonly used anti-malarials and alternative treatment regimens for resistant parasite;
studies on identification of genetic factors in human involved in natural resistance to malaria
infection; studies on identification of sibling species and genetic structure of malaria vectors
using molecular markers; studies on application of remote sensing and GIS in epidemiology
of malaria to develop strategy for vector control .Development and optimization of new
diagnostic tools for malaria like LAMP assay.
- Undertakes research works on genomic characterization of hepatitis E and A viruses and
genotyping of HBV infection circulating in different parts of Orissa.
- Undertakes studies on hospital and field based surveillance system for diarrhoeal
diseases to monitor spectrum of enteric pathogens; molecular epidemiology and genetic
characterization of V. cholerae strains and other diarrhoeal pathogens.
Haemoglobinopathies and allied disorders
- Study the distribution pattern of genetic abnormalities, clinical spectrum and molecular
characterization of abnormal haemoglobin molecules; G6PD deficiency prevalent in Orissa
and their clinical significance.
Nutrition and tribal health
- Studies on the prevalence of anaemia, vitamin A and iodine deficiency disorders among
the primitive tribes; health and nutritional status of different tribes with special focus on
micronutrients to develop suitable intervention strategy; prevalence of haemoglobinopathies
in the tribal population.
- Culture facility has been established at the Centre to identify multi drug resistance (MDR)
and related research issues in this region.
- Laboratory is being established with facilities for viral isolation, viral antigen detection, viral
serology and molecular diagnostic virology including sequencing and to conduct outbreak
investigation of viral diseases of the region.
- The centre has undertaken translational research on identification of malaria vectors by
molecular method, diagnostic tool for V. cholerae, development of candidate vaccine for
filariasis, diagnostic tool for identification of malaria parasite by loop mediated isothermal
amplification (LAMP) assay.
Resource Development :
- M.Sc Dissertations: Sponsored from different universities of Orissa and other parts of the country including students of ICMR short term fellowship programme.
- Other training programmes: Short term training to the doctors and technicians/paramedics from state health departments and NVBDCP, Delhi. The Centre also provides training on mosquito control to staff of different municipal corporations of the state.
for Doctorate/Masters by a University:
Ph.D. Programme: Recognized by Utkal University, Bhubaneswar (Orissa) and Kalyani University, Kalyani (West Bengal).
Significant achievement of RMRC, Bhubaneswar are the following
- First to standardize tissue tonometry for assessing progression of
- First to describe the lymphatic nodules as clinical manifestation of bancroftian
- First to report the use of ivermectin for treatment of scabies.
- Developed the urban strategy of mass drug distribution (MDA) for improvement of
compliance of single dose DEC for elimination of LF.
- Described the potential anti-microfilarial role of ALT2 and CPI2 recombinant antigens.
- Identified a candidate antigen (DssdI) for development of vaccine against bancroftian
- Described a new variant of G6PD enzyme called “G6PD Orissa” among tribal and non-tribal
populations of India.
- Identified a novel allele in the intron 4(VNTR) of endothelial nitric oxide synthase (eNOS) in
our population and association of eNOS polymorphism against cerebral malaria.
- Developed a single tube PCR method to identify mosquito species, presence of sporozoite
and kind of blood meal taken by the vector mosquito.
- Identified pentoxyfiline as an adjunct drug for treatment of cerebral malaria.
- Established a close link with state health system of Orissa to transfer knowledge regarding
vector borne and diarrhoeal diseases.
- Signing of a memorandum of understanding (MoU) between the state health department
Orissa and ICMR to facilitate operational research on cholera control strategy by the Centre