ENTEROVIRUS RESEARCH CENTRE

MUMBAI - 400012


(Established in 1981)

  ENTEROVIRUS RESEARCH CENTRE

Publications

Phone: 022 -24134130
Fax: 022 -24156484
Email : ercgsl@gmail.com, ercicmrmumbai@gmail.com
Scope of Activities:

Situated at Mumbai in Maharashtra the Enterovirus Research Centre (ERC) conducts research on diseases caused by Enteroviruses, especially paralytic poliomyelitis, acute flaccid paralysis, acute haemorrhagic conjunctivitis, aseptic meningitis/ encephalitis and also acute gastroenteritis caused by enteric viruses such as Rotavirus, Norovirus and Enteroviruses.

Thrust Areas:

The following are the thrust areas of ERC

  • Epidemiology of poliomyelitis leading to the understanding of virus transmission patterns for development of policies and strategies for disease control and eradication.
  • Studies on poliomyelitis vaccines such as immunization schedules, vaccination campaigns, evaluation and improvements of vaccine delivery systems.
  • Assistance to the Global Polio Eradication Program through laboratory support for disease diagnosis, understanding disease transmission by molecular epidemiology studies, evaluation of program progress, designing, testing and validating newer assays,
  • Participating in introduction of newer vaccine formulations and contributions to national policy on polio eradication. In Addition to AFP surveillance, Enterovirus Research Centre is carrying supplementary surveillance of wild poliovirus/VPDV by testing sewage samples from selected high risk slum areas in Mumbai since 2001.
International Recognition:

  • ERC is a part of the WHO network of 146 polio laboratories worldwide.
  • ERC based on its contribution to the Polio Eradication Programme, is also a WHO recognised Global Specialized Laboratory for Polio (GSL) the only laboratory, among the seven laboratories so recognized, outside the developed world.
  • ERC is accredited by the WHO for poliovirus investigations
  • WHO network laboratory for Measles and Rubella Surveillance
Human Resource Development :

ERC conducts hands-on training workshops for WHO Polio Network Laboratories of Southeast Asia annually with a focus on laboratory bio-safety, cell culture, virus culture, environmental surveillance and newer molecular diagnostic assays. The Centre offers ad hoc training in these areas.
Recognition for Doctorate/Masters by a University:

ERC is recognized by the University of Mumbai for M. Sc., and Ph. D degrees in Microbiology.

Major Achievements:

  • Enterovirus Research Centre, Mumbai has been recognised and accredited by WHO as National Polio Laboratory since 1997 and also WHO Global Specialized Laboratory for Polio since 2000.
  • Assisted Ministry of Health & Family Welfare, GOI and the WHO in studies carried out for introduction of new polio vaccine formulation and vaccination strategies.
  • Molecular analysis of polioviruses (wild, Vaccine Derived Polio Viruses (VDPV), Sabin-like) to determine genetic relatedness for identification of their transmissibility patterns.
  • Studies Non-Polio Enteroviruses (NPEV).
  • Investigations of Enterovirus-host cell interaction, Toll-like receptors and Cytokines in Enterovirus infections and screening of children with immunodeficiencies for VDPV.
  • Identification of SNPs in Sabin OPV strains and characterization of Sabin OPV polioviruses from AFP cases (VAPP).
  • Development of real time based diagnostic assays for wild polioviruses type 1 and 3.
  • Isolation and molecular characterization of new Enteroviruses EVA121 and EVA114.
  • Participation in National Measles and Rubella surveillance network with NPSP/WHO.
  • ICMR studies on hospital based Rotavirus and Norovirus surveillance.
  • Participation in ICMR Research-cum-Intervention project on JE/AES in Gorakhpur, UP.
  • NIIH and Wadia Hospital, Mumbai collaboration for studying immunodeficient children for long term excretion of polioviruses.
  • Introduction of Oral Polio Vaccine (OPV) in India and generation of epidemiological data on Polio for Mumbai for over 60 years.
  • Molecular epidemiology of wild poliovirus to provide accurate information of virus transmission pathways and guiding polio immunization activities in the country since year 2001.
  • Established environmental sewage samples testing as a surveillance activity supplementing AFP surveillance to detect wild poliovirus circulation in slums in Mumbai.
  • Provided unequivocal data confirming wild poliovirus exportation from India to China (1999), Bangladesh (2006), Nepal (2005) and Angola (2005). Also proved that the wild poliovirus importation in Indonesia was from Nigeria via Saudi Arabia and not from India.
  • Designing, development and evaluation of new testing algorithm for reducing time for reporting wild poliovirus detection in AFP cases resulted in reducing reporting time from 28 days to 14 days. The test algorithm has now been globally implemented.
  • Evaluation of immunogenicity of monovalent, bivalent and trivalent OPV for introduction of new polio vaccines for polio eradication. The trials, having a global significance, were conducted by the WHO in India with ERC as its laboratory partner.
  • Serosurvey of poliovirus antibodies in Moradabad district UP that highlighted the risks of wild poliovirus type 3 and VDPV type 2 in UP and Bihar.
  • Detection and analysis of VDPVs in India.
  • National Task Force (NTF) on polio containment initiated at ERC with nationwide survey of all biomedical laboratories storing wild polioviruses.
  • Reported Coxsackievirus A24 as the etiological agent of an epidemic of AHC in Mumbai in 2007.
  • Reported New Enterovirus 71 genotypes (D and G) from India.
  • Identification of Coxsackievirus A6 and A16 as causative agents of hand, foot and mouth disease outbreaks in Maharashtra, Tamil Nadu and Tripura (2009-2013).
  • Development of a SNP assay to identify mutations and attenuation sites in Sabin Oral Poliovirus vaccine strains.
  • Identification of multiple enteroviruses (CVA2, CVA4, CVA5, CVA10) responsible for causing herpangina outbreaks in children in Thane, Maharashtra in different years.
  • Norovirus outbreak investigation in South Mumbai in 2013.
  • Immunological Characterization of enterovirus EV71 indigenous genotypes.
  • Establishing NGS facility at ERC. /ul>

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