NATIONAL INSTITUTE OF IMMUNOHAEMATOLOGY

MUMBAI - 400012


(Established in 1983)

  NATIONAL INSTITUTE OF          IMMUNOHAEMATOLOGY

Publications

Phone: 022 -24138518
Fax: 022 -24138521
Email : info@niih.org.in
Website :  http://www.niih.org.in
Scope of Activities:

Situated at Mumbai in Maharashtra, the National Institute of Immunohaematology (NIIH) conducts research on various haematological disorders.

Thrust Areas:

The following are the thrust areas of NIIH

  • Study from population to molecular levels of Haemoglobinopathies, Thalassemia, Red Cell Enzymopathies and Membrane disorders.
  • Pilot projects to assess the control and smoother management of these disorders in our country.
  • Prenatal diagnosis of all inherited severe haematological disorders, for which no effective treatment/ cure is available, including in addition, haemophilia, other congenital coagulation disorders, severe immunodeficiencies etc.
  • Cytogenetics, immunophenotypic studies of acute leukaemia, haemopoietic stem cell expansion and differentiation programmes.
  • Cost effective treatment modalities for various haematological disorders.
  • Molecular studies of major blood group antigens, HLA and immunogenetics.
  • Developing Centres of Excellence for congenital immunodeficiency.
  • Developing collaborative centre for research in haemato-virology.
International Recognition:

  • NIIH is recognized as World Federation of Hemophilia (WFH) training centre in genetic diagnosis of hemophilia for South East Asia.
  • WHO has recognized NIIH as a
    • Training centre listed under its Regional Directory of Training Institutes.
    • Training centre in “Transfusion Medicine” and “Advanced Haematology and Immunohaematology” for its in Country Fellowship Training Programme.
  • Recognition by INSERM (Paris) as international associate laboratory.
Human Resource Development :

  • NIIH has been training Blood Bank Medical Officers and Technicians from all over India, with special emphasis on backward areas of the country, for the past 35 years.
  • The International Centre for Scientific Research (ICSR) has included the Institute’s name in its list of research institutes in the world.
  • The Institute has conducted several hands on training workshops sponsored by DBT, WHO, Red Cross, State Blood Transfusion Council, etc where advanced training in specific subjects is given to the trainees.
  • The Institute has been conducting NACO and MDACS sponsored special adhoc training programmes for doctors and technicians for HIV testing since 1985.
  • The Institute undertakes M.Sc dissertation projects of Mumbai and other universities for 6 months.
Recognition for Doctorate/Masters by a University:

  • NIIH is recognised by the University of Mumbai for M.Sc and Ph.D in Applied Biology and Biochemistry.
  • The Institute is also involved in training DM (Clinical Haematology) and MD (Transfusion Medicine) students at KEM Hospital under Maharashtra University of Health Sciences.
  • The Institute has 8 guides for Ph.D in Applied Biology and 3 guides for Ph.D in Biochemistry of Mumbai University.

Major Achievements:

Significant achievements of NIIH are the following
  • Discovery of “Bombay Blood, Ina blood group, Hb Ratnagiri, Fibrinogen Mumbai as well as demonstration of several mutations in Hemoglobin, Pyruvate Kinase, Factor VII, Factor X, Factor VIII, Factor IX, Protein C molecules, and Gp IIb, IIIa molecules in Glanzmanns Thrombasthenia.
  • Development of Prenatal diagnosis for various inherited haematological disorders like haemoglobinopathies, thalassemia, and hemophiliac, methodology for non-invasive prenatal diagnosis for β-thalassemia.
  • Identification of some rare as well as novel G6PD variants (G6PD Coimbra, G6PD Namoru, G6PD Niligiri) among primitive tribes of India.
  • Studies on Effect of Hydroxyurea on patients suffering from various hemoglobinopathies
    • Sickle cell anemia
    • β-thalassemia intermedia
    • β-thalassemia major.
  • Tracing of mechanism of thrombocytopenia following dengue virus infection to infection of CFU – Meg colonies.
  • Development of preliminary data on molecular analysis of ABO alleles and D variants in Indian population.
  • Production of Monoclonal antibodies against B antigen, H antigen, Fetal hemoglobin, Factor VIII using hybridoma technology.
  • Development of a diagnostic algorithm for detection of congenital immunodeficiency syndromes.
  • Development of FISH and comparative genomic hybridization techniques for study of MDS, Fanconi’s anemia, Down syndrome etc.
  • Development of a TEG based classification of haemophilia for rational management of these patients.
  • Development of several techniques on mutation detection, VWF binding assay, semiquantitative factor XIII assay, ELISA assay for Factor VIII inhibitors, Spot test for severe Glanzmann’s thrombasthenia (GT), simple flowcytometry based red cell osmotic fragility assay, ELISA based detection of GT carriers. Some of the tests have been patented.

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