NATIONAL JALMA INSTITUTE FOR LEPROSY AND OTHER MYCOBACTERIAL DISEASES

AGRA - 282001


(Established in 1976)

  NATIONAL JALMA INSTITUTE FOR   LEPROSY AND OTHER              MYCOBACTERIAL  DISEASES

Publications

Phone: 0562 -2331751
Fax: 0562 -2331755
Email : kirankatoch@rediffmail.com;
Website :  http://www.jalma-icmr.org.in
Scope of Activities:

Situated at Agra in Uttar Pradesh, the National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJILOMD) conducts research on leprosy, tuberculosis, HIV. Established by the Japanese as India Centre of JALMA (Japanese Leprosy Mission for Asia) in 1963The Institute has a 60 bedded hospital for the treatment and care of leprosy patients. In the outpatient, on an average daily 300 patients are given consultative medical, surgical & preventive care.

Thrust Areas:

The following are the thrust areas of NJILOMD

To develop and standardize techniques of investigation for diagnosis, treatment and assessment for better management of leprosy in close co-ordination with the National Leprosy Eradication Programme (NLEP) in further reducing the disease and preventing deformities.

Early diagnosis and development of tests for early and rapid diagnosis of TB, drug sensitivity testing and designing and evaluating tests for rapid screening of sensitivity profile of Mycobacterium tuberculosis.

Operational research in TB including disease prevalence and drug resistance surveys in several districts of the state, molecular epidemiology in the field area, treatment using RNTCP protocols as well as participation in multi-centric studies for treatment and operational research and undertaking vaccine studies in animals with other partners.

In HIV as the NACO centre for ICTC to engage in the diagnosis and counseling as well as monitoring of anti retroviral therapy to patients of the medical college.

To pursue the following activities:

Developing newer modified methods of early diagnosis, assessment of treatment and also investigating the disease at patient and community level in both TB and leprosy.

Improving the methods of treatment in both the diseases and participating in multi-centric trials and studies in both TB and leprosy.

Conducting epidemiological studies such as intervention studies, investigations related to transmission and factors leading to reactions and preventing nerve damage in leprosy.

Participating in operational surveys for disease prevalence & drug resistance surveillance in TB.

Training to medical professionals in private sector and those engaged in National Leprosy Eradication Programme (NLEP).

Transferring the technologies developed/established at the Institute to other scientists and medical professionals working in different institutions in the country.

Education and training to students, professionals, health workers for human resource development.

Upscaling and accreditation of Intermediate Reference Laboratories of RNTCP οοprogramme for drug resistance testing in TB in four states Assam, Himachal Pradesh, Uttarakhand and Western UP.

International Recognition:

3.1 Participating centre in WHO multi-centric studies on Uniform MDT for all types of leprosy patients.

3.2 It is also the surveillance centre undertaking molecular detection of drug resistance in leprosy in coordination with SEARO, WHO.

3.3 Its studies on the use of immuno-modulator Mw as an adjunct to chemotherapy in CAT I and CAT II pulmonary tuberculosis approved by the FDA, USA.

Human Resource Development :

4.1 NJILOMD undertakes various training programmes as mentioned below

Two day training programme on leprosy for district leprosy officers, medical officers; training οοon methodology of drug resistance surveys in TB and EQA for smear microscopy.

Training of medical graduates of local SN Medical College as per the curriculum. οο

DBT multi-centric collaborative projects & trainings to various categories of personnel on οοmolecular techniques (average 12-20 per year) to all categories of technical and scientific staff for over two decades.

Teaching research & training support for M.Sc. in Life Sciences (Microbiology, Biochemistry οοand Biotechnology) to Bhim Rao Ambedkar University, Agra since 1998.

Short term trainings, specialized trainings and capacity building trainings were imparted to οοmore than 1000 aspirants of various other colleges/universities/institutions, etc.

Drug resistance surveillance (DRS) training in TB to medical and paramedical staff of 35 οοdistricts of Bundelkhand and Western UP since 2007.

4.2 Having been recognized as a National Reference Laboratory (NRL) for RNTCP activities of Central TB Division of Government of India NJILOMD is providing training in laboratory diagnosis especially molecular techniques for diagnosis and drug resistance studies on tuberculosis since 2008.

Recognition for Doctorate/Masters by a University:

5.1 NJILOMD has entered into MOUs with a number of universities for registering PhD students and for M.Sc dissertation projects

PhD students from

i. Bhim Rao Ambedkar University, Agra

ii. Jiwaji University, Gwalior

iii. Panjab University, Chandigarh

iv. Rani Durgavati Vishwavidyalaya, Jabalpur

M.Sc dissertation from

i. Jiwaji University, Gwalior,

ii. Rani Durgavati Vishwavidyalaya, Jabalpur

5.2 Students from Bhim Rao University, Agra, and other regional and national universities are also considered for M.Sc project dissertation.

 

Major Achievements:

Significant achievements of NJILOMD are the following

Established state of art laboratories e.g. micro-array lab, proteionomics including MALDI-TOF, two BSL-3 laboratories for microbiology and animal experiments with aerosol facility for MTB infection in guinea pigs.

Established a field centre i.e. Model Rural Health Research Unit at Ghatampur (MRHRU) and a satellite centre at Banda, the main focus of which is to bring technology to the people.

Examination of over 30,000 patients of leprosy annually in the OPD of its hospital and providing care and free diagnosis & treatment in the hospital and field for leprosy, TB, filariasis, etc.

Serves as a National Reference Laboratory (NRL) for tuberculosis for 4 states (Assam, Himachal Pradesh, Uttarakhand and Eastern UP) and repository centre for mycobacterial strains.

Established animal house facility as part of the initiative for detecting multi-drug resistancein leprosy using conventional mouse foot pad methods as well as molecular methods for surveillance of multi drug resistance in leprosy.

Serves as a surveillance centre for AIDS control and has a ICTC clinic. Besides testing of foreign nationals it also undertakes free HIV testing and counseling of referred and voluntary patients of the society.

Evaluated and demonstrated the immuno-prophylactic effect of immuno-modulatorMw on immuno-prophylaxsis of both TB and leprosy.

Designed several new treatment regimens for leprosy.

WHO has adopted modified PB regimen as uniform treatment regimen for all types of leprosy cases.

Established the safety and usefulness of addition of immunotherapy (Mw and BCG to MDT) and is now available in the market for use as Immunovac.

Identified antigenic targets and developed serological tests for leprosy.

Developed new surgical procedures for correction of deformities i.e. JALMA flap for restoration of volume of first web space in muscular atrophy associated with ulnar paralysis in leprosy.

Designed the partial micro array chip for leprosy (metabolic pathways and virulence) and TB (efflux pumps and gene associated quinolones resistance).

Developed new methods for early diagnosis of leprosy using amplification of RLEP, 16s gene region and established it in slit skin smears, biopsy specimens and also in tissue sections using in situ PCR.

Developed in house PCR RFLP based method to differentiate mycobacterial isolates (M tuberculosis, M avium, M fortuitum and other pathogens).

Developed molecular typing methods for studying the strain variations in M leprae for identification of sources and mode of transmission.

Established the presence of live bacilli in the environment (soil and water samples) by molecular methods.

Established a network of institutes/ centres working in leprosy for detection of multi-drug resistance in leprosy using mice model as well as molecular methods.

Established a national repository for mycobacteria, networking 38 Institutes and Medical Colleges, and supplying various strains to scientists.

Coordinated multi-centric studies on molecular methods (PCR based) for diagnosis of tuberculosis

Developed methods for molecular diagnosis of Kala Azar.

Undertaking Government of India sponsored and UP Government funded drug resistance surveys (DRS) in 35 districts of Bundelkhand and Western UP region (in collaboration with STDC Agra and UP Government).

Part of DBT sponsored multi-centric studies of use of immuno-modulator Mw as an adjunct to chemotherapy in Cat I Na Cat II tuberculosis.

1175 project dissertation theses, 213 MD theses, and more than 35 PhD theses have been completed, with entire or part of the work performed at NJILOMD, and submitted at various educational institutes/universities.


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