RAJENDRA MEMORIAL RESEARCH INSTITUTE OF MEDICAL SCIENCES

PATNA - 800007


(Established in 1981)

  RAJENDRA MEMORIAL RESEARCH     INSTITUTE OF MEDICAL SCIENCES

Publications

Phone: 0612 -2631565
Fax: 0612 -2634379
Email : rmrims@rmrims.org.in,
Website :  http://www.rmrims.org.in
Scope of Activities:

  • Situated at Patna in Bihar State, the Rajendra Memorial Research Institute of Medical Sciences (RMRIMS) conducts research on various aspects of Visceral Leishmaniasis, also known as Kala-azar, and HIV/AIDS. Tuberculosis is now being included.
  • RMRIMS is one of the designated ICMR centres for bio-medical informatics.

Thrust Areas:

The following are the thrust areas of RMRIMS

  • PCR based diagnosis
  • Studies on VL-HIV co-infection
  • Clinical trials
  • Cost effective integrated vector management
  • Leishmania repository
  • Role of cytokines in responsive and unresponsive patients
  • Immuno-pathology of PKDL patients
  • Innate immunity in malnutrition
  • Database design of leishmania parasite
  • Routine Biochemical and Hematological Diagnosis and Treatment of VL/PKDL/HIV
  • HLA Typing of VL Patients
  • Studies on Drug Resistance Mechanism in Genomic and Proteomic Level
International Recognition:

RMRIMS is a declared WHO reference centre for Leishmania Parasite and Sera Bank.
Human Resource Development :

RMRIMS is providing
  • Training to Masters and P.G. students of Life Sciences.
  • Teaching and training to M. Pharma students.
  • Training to District Medical Officers in Kala-azar control programme.
  • Training kala-azar technical supervisors(KTS) and vector borne disease(VBD) consultants
Recognition for Doctorate/Masters by a University:

RMRIMS is recognized for Doctorate programme by T.M. Bhagalpur University, Bhagalpur, Calcutta University, Kolkata and Patna University, Patna.

Major Achievements:

Among the major achievements of RMRIMS are the following:
  • Establishment of a repository of 22 different isolates of Leishmania; preservation of 119 sera samples of various categories of Kala Azar patients for future work.
  • Successful demonstration of the use of plants’ extract as animal product free culture medium for propagation of Leishmania promastigotes.
  • Successful application of PCR as better diagnostic test for Kala-azar, with encouraging results as compared to conventional microscopy of bone marrow/ spleenic aspirate, and similarly also in PKDL cases, especially with macular lesion, where sensitivity of conventional microscopy of slit kin/ biopsy is very poor.
  • Various clinical drug trials for treatment of VL, PKDL and co-infection and also to assess the safety and efficacy of combination therapies in shorter duration. Some clinical trials undertaken by RMRIMS along with names of the funding agencies are mentioned below:
    • Dose finding study of Miltefosine in treatment of PKDL (WHO/TDR)
    • Paromomycin Phase IV study (iOWH)
    • Combination therapy of Ambisome, Miltefosine and Paromomycin for treatment of VL (DNDi)
    • Combination therapy of Miltefosine and Ambisome for treatment of VL (WHO/TDR)
    • Single low dose of ambisome for treatment of VL (MSF-Spain)
    • Treatment of Kala-azar co-infected with HIV/ Tuberculosis (MSF-Spain)
    • Validation of sand fly distribution and Kala-azar disease prevalence through remote sensing & GIS in endemic and non endemic foci of Kala-azar to re-assess its applicability for the entire Kala-azar endemic region.
    • LEISH DNAVAX trail
  • Re-establishment of the “Integrated Counseling and Testing Centre (ICTC)” for HIV/ AIDS.
  • Establishment of “anti-retroviral treatment (ART)” centre.
  • Establishment of “virology laboratory” for swine flu diagnosis & other viral diseases.
  • Establishment of “tuberculosis laboratory”

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