PRAKASH KUMAR SAHOO
SCIENTIST B

  PRAKASH KUMAR SAHOO

Publications

Date of Joining Present Post: 10-06-2014

Address (Off):

REGIONAL MEDICAL RESEARCH CENTRE
CHANDRASEKHARPUR
BHUBANESWAR - 751023 .
Email : shuvaprakash@gmail.com, sahoopk@icmr.org.in
Educational Qualifications:

M.Sc(Zoology), Ph.D(Immunology)

Discipline:
IMMUNOLOGY



Research Experience:
28 years research experience in the field of Immunology of Filariasis, Malaria and Leptospirosis
Membership/Fellowship of Professional Societies/Associations :

1. Indian Immunology Society
2. National Academy of Vector and Vector Bourn Diseases
3. Indian Association of Laboratory Animal Scientists

Major Achievements :


Lymphatic filariasis and Malaria are two important diseases of the tropics and India contributes a substantially to the disease burden pool of the Southeast Asian countries. In India the incidence of both the diseases are highest in Odisha.

  • Though the disease was known from the prehistoric days the natural history of filariasis was not known. In a long term cohort study we have shown how the static immunological basis plays a role in the development of the disease.
  • The protective immunity in filariasis is questionable. In an epidemiological study we have observed that the anti microfilarial immunity in human lymphatic filariasis operates through antibodies to microfilarial sheath.
  • By using XID mice as an animal model we have shown role of B-1 cell and nitric oxide in the immunopathogenesis of the disease.
  • In case of malaria the role of micro particles and TNF-α in manifestation of severe disease has been elucidated by our group and we have shown that treatment of patients with chloroquine (CQ) along with pentoxifylline (TNF α inhibitor) can reduce the malarial severity and death.
  • Co-infection of filariasis and malaria is very common in tropical countries. Malaria is not influenced by the pre existence of filariasis but decreased prevalence of sepsis is associated with presence of active filarial infection. Systemic helminthes and intestine helminthes are very common in the filarial endemic area. We have observed biannual dose of albendazole can reduce the prevalence of active filarial infection particularly patients having intestinal worm.


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