SHUBHANKAR KUMAR SINGH
SCIENTIST D

  SHUBHANKAR KUMAR SINGH

Publications

Date of Joining Present Post: 01-09-2016

Address (Off):

RAJENDRA MEMORIAL RESEARCH INSTITUTE OF MEDICAL SCIENCES
AGAMKUAN
PATNA - 800007 .
Telephone (off): 0612-2631561
Fax : 0612-2634379
Email : sksrmri@yahoo.com
Educational Qualifications:

  1. B. Sc. Hons. (1993): 1st Div.
  2. M.Sc. (1995): 1st Div.
  3. Ph.D. (2010)

Discipline:
IMMUNOLOGY



Research Experience:
  • Research Assistant, Rajendra Memorial Research Institute of Medical Sciences, Patna.,21.03.2001-30.06.2008
  • Scientist B, Rajendra Memorial Research Institute of Medical Sciences, Patna, 30.06.2008-till date.
Workshops/Conferences/Symposiums :

  • ICMR/WHO/TDR sponsored workshop for investigators of Phase IV Miltefosine for the treatment of Visceral Leishmaniasis on 26th to 28th May 2002 at RMRIMS (ICMR) Agamkuan, Patna-7.
  • Attended National Symposium on Plant Biotechnology: role of sustainable development and 25th Meeting of Plant Tissue Culture Association (India), February 17-19th 2003.
  • Attended conference of 3rd Convention of Society for Immunology and Immunopathology, 13-15 February 2004 at CJIL, Agra and presented paper “Role of Azadirachta indica A. Juss. antigen in modulation of signal transduction for T-cell activation in VL”.
  • Workshop on “Molecular & Immunological Methods” (PCR, RFLP, RAPD, Microarrays etc.) organized by SIIP on Feb 15th 2004 at CJIL, Agra.
  • Attended 33rd Indian Immunology Society Conference (28th-31st January 2007) on Molecular and clinical immunology in health and disease at Department of Biochemistry, AIIMS, New Delhi-110029, India.
  • Successfully completed Advanced Course on Immunology, Vaccinology and Biotechnology Applied to Infectious Diseases (in English) from 4 Sept. to 18 Oct. 2007” organized by UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), WHO, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland at WHO Immunology Research and Training Centre IRTC; Department de Biochimie, University of Lausanne, Switzerland.
  • Attended 10th Indo-US Cytometry Workshop at Institute of Life Sciences, Bhubaneswar from 13th Feb. 2009 to 21st Feb. 2009. Organized by Institute of Life Sciences Bhubaneswar, India and Department of Pathology, Miller School of Medicine, Univ. of Miami, USA.
  • Attended workshop on “Good Clinical Laboratory Practice Training Course” sponsored by UNICEF, UNDP, World Bank, WHO special programme for Research & Training in Tropical Disease (TDR) from 4th to 6th August 2009.
  • Attended the workshop on Preparing/Writing Manuscript in Medical Journals jointly organized by MSF and RMRIMS on 28th October 2009 at RMRIMS, Patna.
  • Attended International symposium on current trends in Pharmaceutical Research on Orphan Disease: Organized by NIPER-Hajipur at Patna, on 10th Jan, 2010.
  • Participated in the BD-RMRIMS Workshop on Basic and Research Applications of Flow Cytometry organized by Rajendra memorial Research Institute of Medical Sciences (ICMR) and Becton Dikinson (BD) India Pvt. Ltd. from 27th April-1st May, 2010 as a Resource Person.
  • Visited Berlin for training and optimization of protocol for vaccine development project LeishDNAVax under European Union Framework Programme 7 (EU FP7) at Charite – Universitatsmendizin Berlin, Medical School of the Humboldt University and the Free University in Berlin, Germany in Oct. 2010.

Awards:
Awarded Fellowship by the Govt. of Switzerland for Advanced Course on Immunology, Vaccinology and Biotechnology Applied to Infectious Diseases (in English) from 4 Sept. to 18 Oct. 2007” organized by UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), WHO, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland at WHO Immunology Research and Training Centre IRTC; Department de Biochimie, University of Lausanne, Switzerland.

Major achievements:

The immunological studies based on evaluation of immunodiagnostic tests as well as studies on cellular mechanism of immunosuppression in VL are the key areas mainly addressed by the investigator. Besides ascertaining value of direct agglutination test (DAT) in serodiagnosis and to identify asymptomatic infection in community, usefulness of other immunodiagnostic tests such as freeze-dried DAT, rK-39, rK26 and KATEX have also been reported by the investigator in a WHO/TDR sponsored project. Visceral Leishmaniasis is a macrophage-associated disorder where, inability of T cells to support macrophage function often results in exacerbation of disease. It was reported by investigator that infection with L. donovani induces less CD2 on the surface of CD4+ T-cells, which once activated orchestrate the protective IFN-g dominant host defense mechanism via PKC-mediated signal transduction and cell proliferation. Many antigens with immunoprophylactic potentials have been identified, particularly 17 and 63kDa. Work was carried out to modulate CD4 cell response in VL patients with certain Leishmania antigens as immunoprophylactic candidate. Besides, at least five components from different plants with pronounced anti-leishmanial effect has been explored. The investigator also explored the immunoprophylactic capabilities of few of these substances through its effect on cell proliferation, activation and effecter function. Presently I am working on Leishmania antigen responsible for regulatory function of Natural T-regulatory cells in VL.

Foreign Visits:
  1. PARTICIPATION IN THE TRAINING AND OPTIMIZATION OF PROTOCOLS FOR THE CLINICAL RESEARCH. TO GERMANY
    FROM 2010-10-18 TO 2010-10-22


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