SAMPADA D. DHAYARKAR
SCIENTIST C

  SAMPADA D. DHAYARKAR

Publications

Date of Joining Present Post: 01-09-2013

Address (Off):

NATIONAL AIDS RESEARCH INSTITUTE
P.B.NO.1895 :73, G BHOSARI IND ESTATE
PUNE - 411026 .
Telephone (off): 020-27331200
Fax : 020-271210731
Email : sdhayarkar@nariindia.org, sdhayarkar@gmail.com
Educational Qualifications:

  • MBBS, 2003 Pad. Dr. D. Y. Patil Medical college, Pimpri, Pune, MUHS Nashik University

Discipline:
EPIDEMIOLOGY
MEDICAL STATISTICS


Research Experience:

National Projects (Principal or Co Principal Investigator) 

Prevention of recurrence of bacterial vaginosis in HIV infected women with lactobacilli containing vaginal tablets to the standard oral metronidazole therapy: A 12-month, double-blind, randomized, placebo-controlled study. 
Approved by funding agency 
Role: Principal Investigator 
2. Study for identification of cell signaling pathways modulated by HIV and their possible role in HIV persistence after activation 
Submitted to DBT 
Role: Co Principal Investigator

National Projects (as sub-investigator/study coordinator) approved with international funding ICMR – CONRAD study 
Preparing sites for conducting effectiveness trials of microbicides in India at three sites in India- Maharashtra, Karnataka & Andhra Pradesh 
Role: Study Coordinator. 
Study: Ongoing

International Projects (as co-investigator/sub-investigator) approved with international funding ongoing studies 
1. Clinical Trial Unit: An NIH funded unit [PI: Dr. AR Risbud] 
2. HPTN 052 study [IoR: Dr SV Godbole] 
A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 In Serodiscordant Couples (HPTN 052) 
Role: Study Coordinator

Completed studies 
Role: Sub investigator 
1. ACTG 5175- [PI: Dr SP Tripathy] 
This is a phase IV prospective, randomized open label evaluation of the efficacy of once daily protease inhibitor and once daily non nucleoside reverse transcriptase inhibitor containing therapy combinations for initial treatment of HIV-1 infected individuals from resource limited settings (PEARL) trial.
2. ACTG 5199 [PI: Dr SP Tripathy] 
Neurological study to estimate the prevalence of ADC in participants in resource limited settings who have advanced disease (< 300 CD4 cells count/cu mm) and who are treatment naive. Also to estimate the prevalence of HIV related neurological OI in participants in resource limited settings who have advanced disease (< 300 CD4 cells count/cu mm) and who are treatment naïve and to estimate changes in neurocognitive functioning with initiation of ART regimen in resource limited settings 
3. ACTG 5221 [PI: Dr SP Tripathy] 
STRIDE: A Strategy Study of Immediate Versus Deferred Initiation of Antiretroviral Therapy for AIDS Disease-Free Survival in HIV-Infected Persons Treated for Tuberculosis with CD4 < 250 Cells/mm3 
4. ACTG 5253 [PI: Dr SP Tripathy] 
Sensitivity and Specificity of Mycobacterium Tuberculosis Screening and Diagnostics in HIV-Infected Individuals; A Multicenter Trial of the AIDS Clinical Trials Group (ACTG) 
An exploratory, observational, prospective, cross sectional study designed to construct diagnostics strategies for identifying pulmonary TB in HIV-1 infected participants.
5. ACTG 5271- [PI: Dr SP Tripathy] 
This is an observational study to evaluate neurocognitive functioning of HIV uninfected individuals in Resourced-Limited Settings.

Institutional Activity 
Care Protocol 
A protocol for providing standardized care and support to HIV infected individuals attending NARI clinics and to create and maintain a uniform database across all the clinics for all referred individuals and previous NARI participants. 
Role: Lead Implementation Team Member 

Administrative experience 
Supervision of all clinic related activities of NARI-NIV clinic and shouldering all administrative responsibilities in the capacity of clinic in charge

Faculty for Trainings / Guest Lecturers 
1. Guest Lecture for Medical Officers on Universal Precautions and Bio medical Waste management under NACO Training Programme 2008 conducted by NARI ART center on 23 Jun 2008. Contributing to NACO training programme. 
2. Regularly conducting trainings on “Bio-safety in clinics and post exposure prophylaxis” for new staff during the orientation programme. 
3. Lecture on “Natural History of HIV infection” conducted regularly as a part of Orientation Programme for new staff at NARI 
4. Training on Source Documents and Case Report Forms of HPTN 052 study for clinicians and DMC staff at National AIDS Research Institute. 
5. HPTN 052 Protocol Specific training for new staff 
6. ICMR CONRAD Protocol Specific training for NARI as well as staff of all study sites 

Presentations at Conferences 
1. Acceptance of ART in the Delay Arm after Notification of Interim Study Results: Data from HPTN 052 (Presented at CROI 2013) 
T. Gamble, PhD1; M. McCauley, MPH2; J. Talley, MA1; P. Dusara, MBChB3; M. Maliwichi, MBBS4; N. Kumarasamy, MBBS, PhD5; J. Batani, BA6; F. Matchere, MPH7; G. Calvet, MD, MSc8; T. Brum,MD9; S. Dhayarkar, MBBS10; S. Chariyalertsak, MD, DrPH11; R. A. Lira, MD12; S. Govender, MD13; S. Badal-Faesen, MD14; X. Li, PhD15; M. Cohen, MD16 for the HPTN 052 Study Team 
2. Abstract presented in International Conference on Fundamental and Translational Research on HIV/AIDS: Global Perspectives organized by NIRRH, Mumbai 
Incidence and mortality due to tuberculosis in a cohort of 300 HIV infected patients in Pune, India 
Tripathy S, Ghate M, Sane S, Dhayarkar S, Chunkhade S, Wankhede S, Pereira M, Thakar M, Risbud AR, Paranjape RS, Mehendale SM.

Positions and Employment

  • Lady Medical Officer UHTC, Dr. D.Y. Patil Medical College, Pune Jan 2005 - Jun 2005
  • Clinician RS I National AIDS Research Institute, Pune Nov 2005 - Jan2009
  • Study Coordinator, HPTN 052 study, NARI National AIDS Research Institute, Pune Jan 2009 - till date
  • Scientist B, Epidemiology & Biostatistics National AIDS Research Institute, Pune Feb 2009 - till date
Current Positions held at NARI
  • Scientist B, Epidemiology & Biostatistics Department
  • Clinic in charge, NARI NIV clinic, NIV Campus, Ambedkar Road, Camp, Pune
  • Study Coordinator
    • HPTN 052 study (Jan 2009 - till date)
    • ICMR-CONRAD study (Mar 2009 - till date)
Positions held in past: CRS Coordinator, NARI CRS, Clinical Trials Unit (Feb 2009 - Jan 2012)

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