MAMTA CHAWLA SARKAR
SCIENTIST E

  MAMTA CHAWLA SARKAR

Publications

Date of Joining Present Post: 01-09-2014

Address (Off):

NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES
P-33, CIT ROAD SCHEME XM P.O.BOX 177 BELIAGHATA
KOLKATA - 700010 .
Telephone (off): 91-33-23537470,23701176
Fax : 91-33-23632398
Email : sarkarmc.niced@gov.in, chawlam70@gmail.com
Discipline:
VIRUS DISEASES
MOLECULAR BIOLOGY


Research Experience:
Dr. Chawla-Sarkar did her Post-doctoral research work as Research Associate from Feb 1999– Nov 2003 in Center for drug discovery & development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland. The research project was on analysis of the genes involved in antitumor effects of IFNs and the mechanisms underlying IFN resistance in tumors of different histopathologies. During her tenure, she was awarded the research award (2002-2004) for a study on “Evaluation of Bcl2-Antisense oligonucleotide (Genasense) and IFN as co-therapeutic agent in-vitro in solid tumor cell lines”. On completion of the project, she shifted her research focus in Immunology from 2004-2005 to understand the role of heme insertion in dimerization and activity of inducible nitric oxide synthetase and study the effect of heme binding inhibitors in modulating NOS activity in various pathological disorders. In January 2006, Dr Chawla-Sarkar joined in Division of Virology at NICED as Scientist C. In 2014, she was promoted to Scientist E. Her research focus involves strain surveillance, Host-virus interaction and identifying cellular proteins involved in viral pathogenesis for developing potential antiviral targets with focus on Influenza and Rotavirus. She is the coordinating scientist for ICMR’s National Rotavirus Surveillance Network and Influenza Surveillance for Eastern India. Dr. Chawla-Sarkar was responsible for providing laboratory support in West Bengal during A/H1N1 outbreaks in 2009 and 2015.
Membership/Fellowship of Professional Societies/Associations :
  1. Member of Indian Science Congress
  2. Member of Society for Biological Chemists
  3. Member of Indian Virological society
  4. Fellow of the National Academy Of Science in India ( NASI)
Workshops/Conferences/Symposiums :

  1. Modulation of both cell survival and apoptotic pathways during virus infection by rotavirus encoded non-structural proteins. M. Chawla Sarkar. 12th International dsRNA Virus Symposium 2015, Goa. 6-10th October 2015. (Oral presentation)

  2. miR-142-5p Augments Rotavirus Infection by Targeting Non Canonical TGFβ Signaling and Apoptosis. S. Chanda, S. Nandi, M. Chawla-Sarkar. 12th International dsRNA Virus Symposium 2015, Goa. 6-10th October 2015. (Poster presentation)

  3. Calmodulin Positively Regulates Rotavirus Infection by Modulating Host Cell Cycle Progression” M Chawla Sarkar. 17th International Conference on Emerging Infectious Diseases (EID) meeting at Taipei, Taiwan 25-29 Jan 2015. (Oral Presentation).

  4. Rotavirus modulates activity of antiviral protein Viperin to combat host induced IFN responses during infection. Satabdi Nandi, Shampa Chanda and Mamta Chawla-Sarkar. (Oral Presentation). 17th International Conference on Emerging Infectious Diseases (EID) meeting at Taipei, Taiwan 25-29 Jan 2015.

  5. Surveillance and genetic Analysis of Influenza virus strains in eastern India. International workshop on Epidemiology and Control of Influenza, VPCI and APAC, Delhi during 7-8 Nov 2014. (Oral presentation).

  6. Rotavirus encoded non-structural protein 1 modulates cellular apoptotic machinery by targeting tumour suppressor protein p53. R. Bhowmick and M Chawla Sarkar . Eleventh International Rotavirus Symposium 3-5 Sept 2014, New Delhi.

  7. Hospital Based surveillance and genetic characterization of rotavirus strains in children (< 5years) with acute gastroenteritis in Kolkata revealed resurgence of G9 and G2 genotypes during 2011-2013. S. Mullick, P. Mandal, M.K. Nayak, K Rajendran, MK Bhattacharya, T Ramamurthy, M Chawla Sarkar. Eleventh International Rotvirus Symposium 3-5 Sept 2014, New Delhi.

  8. Multiple functions of Rotavirus encoded Nonstructural proteins (NSPs) for Combating host Responses during Infection. R Bhowmick, P Bagchi, N Kobayashi and M Chawla-Sarkar. Asian-African Research Forum on Emerging and Reemerging Infections, Sendai, Japan, 20-22 Jan 2014. (Oral [S3-3] and Poster [P-046] presentation).

  9. Dual role of Matrix 1 protein in modulation of apoptosis during Influenza virus infection". M Chawla Sarkar and U C Halder. 5th Congress of European Microbiologists (FEMS),Leipzig, Germany during July 21-25, 2013.

  10. Multiple Strategies adopted by Rotavirus encoded Non structural protein ( NSP1) for evasion of cellular responses". M Chawla-Sarkar, R Bhowmick and P Bagchi . 5th European Rotavirus biology Meeting Valencia, Spain, 6-9 October 2013 (Oral Presentation)

  11. Community based case-control rotavirus surveillance study among Children ( < 5 yrs old) revealed coexistence of large number of Genotypes and increased prevalence of G9 strains in Kolkata. S. Mullick, S. Ghosh , T.. Ramamurthy and M Chawla-Sarkar. 5th European Rotavirus biology Meeting Valencia, Spain, 6-9 October 2013 (Poster presentation).

  12. Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of Influenza A Matrix 1 function” M Chawla-Sarkar and U C Halder. 3rd Molecular Virology Meeting, Jan 10-11, 2013 (Oral Presentation).

  13. Modulation of cellular apoptosis by Rotavirus nonstructural proteins 9NSP4 and NSP1) for efficient viral infection” R. Bhowmick, P Bagchi and M. Chawla Sarkar. 100th Indian Science Congress, Medical Sciences Section, 3-7 January, 2013. (Oral Presentation).

  14. Modulation of both cell survival and apoptotic pathways during virus infection by rotavirus encoded non structural-4 (NSP4) and non structural-1 (NSP1) proteins. M Chawla Sarkar, R Bhowmick, P Bagchi, N. Kobayashi. The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine, Sapporo, Japan, 16-18th October 2012. (Poster presentation PS II-8).

  15. Role of rotavirus encoded non structural proteins in modulation of cell death during infection” R Bhowmick, U C Halder, P Bagchi and M Chawla-Sarkar. 2nd International Conference on Perspectives of Cell Signaling and Molecular Medicine, Bose Institute, Kolkata, India, Jan 8-11 2012.

  16. Modulation of cellular apoptosis by Influenza viruses during infection: role of Matrix 1 ( M1) protein.” U C Halder, R. Bhowmick and M Chawla Sarkar. Virocon 2012; XX1 National Conference on Immunobiology and Management of Viral Diseases in 21st Century, Indian Veterinary Research Institute, Mukteshwar, India, 8-10th Nov 2012.(Oral Presentation)

  17. Case-Control community based rotavirus surveillance study in Kolkata revealed increased prevalence og G9, G12 and unusual animal like strains. M Chawla Sarkar. Virocon 2012; XX1 National Conference on Immunobiology and Management of Viral Diseases in 21st Century, Indian Veterinary Research Institute, Mukteshwar, India, 8-10th Nov 2012. (Invited Lecture)

  18. Influenza A virus encoded matric protein modulates cellular apoptosis for efficient viral infection” U C Halder and M Chawla Sarkar . 2nd International Conference on Perspectives of Cell Signaling and Molecular Medicine”, Bose Institute, Kolkata, India, Jan 8-11 2012.

  19. Matrix-1 protein of Influenza A virus promotes apoptosis via caspase-9 pathway by inhibiting Hsp70-Apaf1 interaction”. U C Halder and M Chawla-Sarkar. 4th European Congress of European Microbiologists (FEMS 2011), Geneva, Switzerland, June 28-30 2011.

  20. Cellular chaperone Heat Shock Protein-90 positively regulates rotavirus infection by modulating the virus encoded Non structural protein. Dipanjan Dutta, Nobumichi Kobayashi, and Mamta Chawla-Sarkar. IUMS 2011 ( XV International Congress of Virology), Sapporo, Japan Sept 11th -16th 2011.

  21. Hsp90 positively regulates Rotavirus Infection by Modulating the Function of Cellular Protein AKT and virus encoded Non structural Protein-3. D Dutta, S. Chattopadhyay and M Chawla-Sarkar. Annual Conference of International association of Medical and Pharmaceutical Virologists, University of Delhi, New Delhi, India, 3rd- 5th March 2011. (Oral Presentation)

  22. Analysis of Antiviral activity of Biacilin, against Influenza A viruses (A/H1N1/2009) reveals its role in modulating cellular responses”. M K Nayak, A. S. Agrawal, S. Sarkar and M. Chawla-Sarkar. 2nd Annual Conference of International association of Medical and Pharmaceutical Virologists, University of Delhi, New Delhi, India, March, 3rd-March 5th 2011.

  23. Comparitive analysis of full genome expression profile of host cells following infection with rotavirus strains from human and animal origin” P. Bagchi, S. Chattopadhyay, R. Bhowmick and M. Chawla-Sarkar. International symposium on Molecular and Pathophysiological Research on Enteric Pathogens, Kolkata, India, Jan 27-29, 2011.

  24. Surveillance for Influenza A viruses during 2009 Pandemic revealed co-circulation of seasonal Influenza strains with pH1N1/2009 in Eastern India. M. Sarkar, T Roy, A. Mukherjee, A. Agrawal, S. Chakrabarti and M Chawla-Sarkar. Options for the control of Influenza VII, Hongkong, Sept 3-7 2010.

  25. Surveillance and Genetic analysis of Human Influenza A ( A/H3N2 & A/H1N1) virus strains circulating during 2005-2009 in Kolkata, Eastern India. A. Agrawal, M. Sarkar, S. Ghosh, S. Chakrabarti, A. Mishra, M. Chawla-Sarkar. Options for the control of Influenza VII, Hongkong, Sept 3-7 2010.

  26. Full genome characterization of Unusual Group A rotavirus strains from India: Evidence of complex interspecies transmission involving multiple gene segments” Anupam Mukherjee and Mamta Chawla-Sarkar. IXth International Rotavirus Symposium, Johannesburg, South Africa, August 2nd-3rd 2010

  27. Rotavirus Modulates The Host Innate Immune Responses By Activating PI3K/Akt And NFκB Pathways During Early Stages Of Infection. Parikshit Bagchi, Dipanjan Dutta, Shiladitya Chattopadhyay and Mamta Chawla-Sarkar. IXth International Rotavirus Symposium, Johannesburg, South Africa, August 2nd-3rd 2010.

  28. Surveillance for Influenza Virus reveals co-circulation of pH1N1 and seasonal influenza strains in Eastern India”. M Chawla-Sarkar, M. Sarkar, T. Roy, a. Mukherjee, S. Chattopadhyay, A C Mishra and S. Chakrabarti in International Conference on Emerging Infectious Diseases, Atlanta, July 11-14 2010.

  29. Increasing evidence of complex zoonotic transmission of human group a rotaviruses in india”. A. Mukherjee & M. Chawla-Sarkar. 4th Euroepan Congress of Virology, Villa Erba Cernobbio, Como, Italy, April 7-11th 2010.

  30. Surveillance of rotavirus strains reveals evidence of emerging G12 and unusual human-animal reassortant strains in Manipur, North-eastern India. A. Mukherjee & M. Chawla-Sarkar. 14th International Congress on Infectious Diseases, Miami, Florida, USA, March 9-12th, 2010.

  31. A two year surveillance for influenza and RSV using Real-time PCR among children with acute respiratory infections in Kolkata reveals distinct seasonality of infection”. A. S. Agrawal, S Chakrabarty & M. Chawla-Sarkar. 14th International Congress on Infectious Diseases, Miami, Florida, USA, March 9-12th, 2010.

  32. Surveillance and genetic characterization of circulating influenza-A virus strains in Kolkata 2005-2008”. A. S. Agrawal, M. Sarkar, S. Ghosh, S Chakrabarty & M. Chawla-Sarkar. ICGEB-IUBMB Workshop on “Humam RNA Viruses”, New Delhi, India, February 10-12th, 2010.

  33. Surveillance and genomic characterization of novel influenza virus (swine H1N1) strains circulating in eastern India”. M. Sarkar, R. Dey, A. S. Agrawal, A. Mukherjee, S. Chakrabarti and M. Chawla-Sarkar. 97th Annual Meeting on Indian Science Congress, Thiruvananthapuram, India from 3-7 Jaunary, 2010. ( Oral Presentation)

  34. Rotavirus NSP-1 suppresses virus-induced cellular apoptosis to facilitate viral growth during early stages of infection”. P. Bagchi, D. Dutta, N. Kobayashi, K. Taniguchi, M. Chawla-Sarkar. Domestic Congress of Virology, Japan, Oct 25-27th 2009. (Oral Presentation)

  35. Molecular chaperone Hsp90 positively regulates rotavirus infection”. D. Dutta, P. Bagchi, N. Kobayashi, K. Taniguchi, M. Chawla-Sarkar. Domestic Congress of Virology, Japan, Oct 25-27th 2009. (Oral Presentation)

  36. Comparative evaluation of multiplex real-time PCR and conventional RT-PCR during a two year surveillance study for influenza and respiratory syncytial viruses among children in Kolkata, India.” A. S. Agrawal, M. Sarkar and M. Chawla-Sarkar. 12th Annual ESCV meeting .Istanbul, Turkey, Sep 27-30th 2009.

  37. Evasion of cellular responses: Multifunctional role of rotavirus nonstructural protein-1”. P. Bagchi, D. Dutta, N. Kobayashi and M. Chawla-Sarkar. International Joint Forum on Infectious Diseases, Bangkok, Sep 16-17, 2009. (Oral Presentation).

  38. Rotavirus Nonstructural Protein-1 Facilitates Virus Growth by Delaying Premature Apoptosis in Infected Cells”. P. Bagchi, D. Dutta, S. Chattopadhyay, A. Mukherjee, N. Kobayashi and M. Chawla-Sarkar. 13th International Conference on Emerging Infectious Diseases in the Pacific Rim, India, April 6-9, 2009.

  39. Host Cellular Proteins: Key Determinants of rotavirus infection and pathogenesis”. D. Dutta, P. Bagchi, S. Chattopadhyay, A. Mukherjee, N. Kobayashi and M. Chawla-Sarkar. 13th International Conference on Emerging Infectious Diseases in the Pacific Rim, India, April 6-9, 2009.

  40. Genomic diversity of human group A Rotaviruses: Increasing evidence of complex zoonotic transmission events”. A. Mukherjee, S. Chattopadhyay, D. Dutta, S. Ghosh, T.N. Naik, N. Kobayashi and M. Chawla-Sarkar. 13th International Conference on Emerging Infectious Diseases in the Pacific Rim, India, April 6-9, 2009.

  41. Host Cellular Proteins; Key Determinants of rotavirus infection and pathogenesis”. D. Dutta, P. Bagchi, N. Kobayashi and M. Chawla-Sarkar. The Asian-African Research forum on Emerging and Reemerging Infections at Sapporo, Japan, Dec 15-16th 2008.

  42. Study of host cellular proteins required for viral replication and pathogenesis during Rotavirus-host cell interactions.” D. Dutta, P. Bagchi and M. Chawla-Sarkar. Keystone symposium on Pathogenesis and Control of Emerging Infections and Drug Resistant Organisms, Bangkok, Oct 22-27, 2008.

  43. Natural plant products: an effective source for developing new anti-influenza virus drugs”. M. Chawla-Sarkar, M. Sarkar, A.S Agrawal and R. Dey. The Third European Influenza Conference at Vilamora, Portugal. Sept 14-17 2008.

Awards:
  • Fellowship of National Academy of Science in India (FNASc) in 2013
  • National Women Bioscientist Award (Young Category) by Dept of Biotechnology (DBT) in 2013
Foreign Visits:
  1. JAPAN-INDIA BILATERNAL MEETING ON THE COLLABORATIVE RESEARCH PROJECTS TO JAPAN
    FROM 2016-01-25 TO 2016-01-26

  2. PARTICIPATION IN THE 4TH CONGRESS OF EUROPEAN MICROBIOLOGISTS TO SWITZERLAND
    FROM 2011-06-26 TO 2011-06-30

  3. PARTICIPATION IN THE 9TH INTERNATIONAL ROTAVIRUS SYMPOSIUM. TO SOUTH AFRICA
    FROM 2010-08-02 TO 2010-08-03

  4. PARTICIPATION IN THE MEETING TO DISCUSS JOINT PROJECT ON EMERGING INFECTIOUS DISEASES WITH NICED. TO BANGKOK
    FROM 2009-09-16 TO 2009-09-17

  5. ASIAN-AFRICAN RES. FORUM ON EMERGING & REMERGING INFECTIONS. & VISIT NAT. INST. OF INFECTIOUS DIS. & INT. MEDICAL CENTRE. TO JAPAN
    FROM 2008-12-14 TO 2008-12-18

  6. PARTICIPATION IN THE THIRD EUROPEAN INFLUENZA CONFERENCE. TO PORTUGAL
    FROM 2008-09-14 TO 2008-09-17

  7. PARTICIPATION IN THE TWO MEETINGS "INDO-JAPAN SYMPOSIUM ON ENTERIC INFECTION" AND "ASIAN FORUM ON INFECTIOUS DISEASES". TO JAPAN
    FROM 2008-01-25 TO 2008-01-29

  8. TO AVAIL TRAINING ON COLLABORATIVE RESEARCH ON ROTAVIRUS IN LAB OF DR. NOBUMICHI KOBAYASHI,DEPTT.OF HYGIENE&EPIDEMIOLOGY TO JAPAN
    FROM 2007-07-16 TO 2007-08-16


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